LFA - 1 , and CD 4 Modulation of
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Evidence for a Dithiol-Activated Signaling Pathway in Natural Killer Cell Avidity Regulation of Leukocyte Function Antigen-l: Structural Requirements and Relationship to Phorbol Ester- and CD16-Triggered Pathways
Dithiothreitol (Dm) activation of the adhesive function of several different integrins suggests the existence of a common DlT-sensitive integrin regulatory element. Uill/E3, a natural killer (NK) cell-resistant murine target cell line genetically engineered to constitutively express human intercellular adhesion molecule-l (ICAM-1; CD%) was used in a flow cytometric experimental model to evaluat...
متن کاملThymocyte binding to human thymic epithelial cells is inhibited by monoclonal antibodies to CD-2 and LFA-3 antigens.
With the use of cultured human thymic epithelial (TE) cells, we have previously shown that thymocytes bind to TE cells in suspension in a rosette-forming assay. To identify cell surface molecules involved in human TE-thymocyte rosette formation, we assayed a large panel of monoclonal antibodies for their ability to inhibit rosette formation. We found anti-CD-2 (LFA-2, T11), and anti-LFA-3 antib...
متن کاملLFA-1 affinity regulation is necessary for the activation and proliferation of naive T cells.
The activation of LFA-1 (lymphocyte function-associated antigen) is a critical event for T cell co-stimulation. The mechanism of LFA-1 activation involves both affinity and avidity regulation, but the role of each in T cell activation remains unclear. We have identified antibodies that recognize and block different affinity states of the mouse LFA-1 I-domain. Monoclonal antibody 2D7 preferentia...
متن کاملTHE LYMPHOCYTE ASSOCIATED LFA - 1 , LFA - 3 MOLECULES " Receptors FUNCTION - CD 2 , and Cell Adhesion of the Immune System
Cell adhesion molecules are thought to play an important role in guiding cell migration and localization in the development of the embryo and in organogenesis. In the immune system, cell adhesion molecules enhance the efficiency of specific receptor-dependent lymphocyte-accessory cell and lymphocyte-target cell interactions ; they are also important in leukocyteendothelial cell interactions and...
متن کاملCell, Tumor, and Stem Cell Biology Comparative Analysis of Normal versus CLL B-Lymphocytes Reveals Patient-Specific Variability in Signaling Mechanisms Controlling LFA-1 Activation by Chemokines
Activation of lymphocyte function–associated antigen-1 (LFA-1) by chemokines is fine-tuned by inside-out signaling mechanisms responsible for integrin-mediated adhesion modulation. In the present study, we investigated the possibility of qualitative variability of signaling mechanisms controlling LFA-1 activation in chronic lymphocytic leukemia (CLL) cells. We pursued a multiplexed comparative ...
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